The University of Michigan Comprehensive Musculoskeletal Center is focused on bringing multidisciplinary care to patients every day. That care relies on cross-disciplinary research that provides clinicians with the latest information and novel approaches to treating chronic conditions.

In August 2016, U-M was awarded a $3.9 million Center of Excellence P30 grant from the National Institutes of Health to strengthen its existing musculoskeletal health research program by accelerating new cross-disciplinary research throughout the university.


James E. Carpenter, MD

“The University of Michigan has an exceptional group of faculty studying musculoskeletal diseases and treatments who will be able to accelerate their research as a result of this award,” says , chair of orthopaedic surgery.

The cross-disciplinary research will happen through the new Michigan Integrative Musculoskeletal Health Core Center (MiMHC).

“The MiMHC was structured to accelerate science and innovation at U-M around understanding mechanisms of musculoskeletal health, injury and disease across the lifespan,” says Karl Jepsen, PhD, professor and associate chair of research of orthopaedic surgery, principal investigator for the grant and director for the MiMHC.

Three main research cores within the MiMHC will focus on histological assessment, structural and compositional assessment, and functional assessment. The cores move from molecular mechanisms through functional outcomes.


Karl Jepsen, PhD

“These cores will enable us to turbocharge bench-to-bedside research,” Jepsen says. “We are very excited to see how new findings influence future therapies, recommendations and training programs.”

Examples of cross-disciplinary research within the MiMHC include investigators in obstetrics and gynecology collaborating with an orthopaedics researcher to understand muscle stretch and function of the pelvic floor during vaginal birth, as well as investigators in orthopaedics, anatomy, anthropology and engineering collaborating together to understand anterior cruciate ligament (ACL) injuries.

“This is an exciting time for those of us in musculoskeletal research,” Jepsen says. “Greater interactions between basic scientists and clinicians are important to the future of medicine and the care we will be able to provide to patients in the years to come.”


Main research cores within
the MiMHC will focus on:

1 Histological assessment

2 Structural and compositional assessment

3 Functional assessment

The cores move from molecular mechanisms through functional outcomes.


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